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GLP-1 pills are on the way. Here's what to know

Drugmakers have developed pill versions of GLP-1 medicines to treat obesity.
David J. Phillip
/
AP
Drugmakers have developed pill versions of GLP-1 medicines to treat obesity.

You may have heard of Ozempic, and other GLP-1 drugs. They're everywhere. But weekly injections, cost, and insurance complications mean they're not for everyone.

That's why there's a lot of excitement around two new pill forms of the drug.

The first is a Wegovy pill that's expected to win FDA approval by the end of the year. Plus another kind of obesity pill that could be right behind it.

The human body naturally makes a hormone called GLP-1, or Glucagon-Like Peptide-1. It helps signal fullness and stimulate insulin secretion in the body. GLP-1 drugs do something similar – but they stick around in the body for longer.

Check out more of NPR's coverage about GLP-1s.

Interested in more health stories? Email us your question at shortwave@npr.org.

Listen to every episode of Short Wave sponsor-free and support our work at NPR by signing up for Short Wave+ at plus.npr.org/shortwave.

Listen to Short Wave on Spotify and Apple Podcasts.

This episode was produced by Rachel Carlson. It was edited by Rebecca Ramirez. Tyler Jones checked the facts. The audio engineer was Kwesi Lee.  

Copyright 2025 NPR

Emily Kwong
Emily Kwong is the reporter for NPR's daily science podcast, Short Wave. The podcast explores new discoveries, everyday mysteries and the science behind the headlines — all in about 10 minutes, Monday through Friday.
Sydney Lupkin is the pharmaceuticals correspondent for NPR.
Rachel Carlson
Rachel Carlson (she/her) is a production assistant at Short Wave, NPR's science podcast. She gets to do a bit of everything: researching, sourcing, writing, fact-checking and cutting episodes.
Brent Baughman
Brent Baughman is a senior producer in the Programming division at NPR, where he works on new and existing podcasts.
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